Abstract
A recently published Viewpoint underscored the importance of T- and B- cell-mediated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but omitted to mention the very first step necessary to trigger those responses, namely the formation of a complex between the virus antigen and a suitably matching Human Leukocyte Antigen (HLA) molecule
Highlights
A recently published Viewpoint[1] underscored the importance of T- and B- cell-mediated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but omitted to mention the very first step necessary to trigger those responses, namely the formation of a complex between the virus antigen and a suitably matching Human Leukocyte Antigen (HLA) molecule
We discuss the role of HLA in individual variability in immune response to SARS-CoV-2, emphasizing the implications of HLA as potentially underlying sustained symptoms seen in “long-COVID”, as distinguished from the severe, acute COVID-19, which is associated with “stormy” immune response
We contend that HLA makeup likely plays a role in sustained symptoms observed in long-COVID and is highly relevant to COVID-19 prevention and intervention
Summary
A recently published Viewpoint[1] underscored the importance of T- and B- cell-mediated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but omitted to mention the very first step necessary to trigger those responses, namely the formation of a complex between the virus antigen and a suitably matching Human Leukocyte Antigen (HLA) molecule. We discuss the role of HLA in individual variability in immune response to SARS-CoV-2, emphasizing the implications of HLA as potentially underlying sustained symptoms seen in “long-COVID”, as distinguished from the severe, acute COVID-19, which is associated with “stormy” immune response.
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