Abstract
Commentary: Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.
Highlights
The recent review by Doyon et al (2016) is for the main part an excellent description of many important aspects of neuronal chloride regulation and will be of good use to many scientists interested in synaptic function
Some information given on the role of the K+ Cl− cotransporter 2 (KCC2) is likely to be misleading
(2016) suggest that this may be due to the small degree of inhibitory synaptic activity in the preparation used, with extremely low Cl− load. They give an equation for the equilibrium relation between Cl− flux through an inhibitory (Cl−) conductance and the Cl− transported by KCC2
Summary
The recent review by Doyon et al (2016) is for the main part an excellent description of many important aspects of neuronal chloride regulation and will be of good use to many scientists interested in synaptic function. They give an equation for the equilibrium relation between Cl− flux through an inhibitory (Cl−) conductance (ginh) and the Cl− transported by KCC2.
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