Abstract
Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Highlights
Specialty section: This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology
High energy UVB is strongly absorbed by epidermal genomic DNA resulting in direct DNA damage by generating two major photoproducts: cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4 PPs), both of which are mutagenic and carcinogenic in animal models as well as in humans (Bowden, 2004; Lima-Bessa and Menck, 2005)
This loss results from transformed melanocytes, while non-melanoma skin cancers originate from malignantly transformed keratinocytes (Kraemer, 1997; Bowden, 2004)
Summary
Specialty section: This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology. Recent findings from two independent research groups suggest that melanin might contribute to additional DNA damage and might further lead to increased risk of skin cancers (Noonan et al, 2012; Premi et al, 2015).
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