Abstract
Commentary: Antidepressants and diabetes risk: why are there discrepant findings from cohort studies based on patient records and those based on serial phenotyping?
Highlights
In the 15-year follow-up, people who had used antidepressants for 2 years or more experienced almost a doubling of later diabetes risk compared with non-users.[4]
If antidepressant use truly increases the risk of diabetes, an association would be expected with undiagnosed disease as well as the metabolic changes that precede diabetes onset, such as elevated fasting glucose and impaired glucose tolerance
Using data from DESIR, an unusually well-characterized population-based cohort study primarily established to examine the insulin resistance syndrome, Azevedo Da Silva and co-workers bring more evidence to bear on the antidepressant medication-diabetes controversy.[3]
Summary
In 2004, the US Food and Drug Administration issued a ‘black-box’ warning on antidepressants (so called because the advisory text on the package insert is required to be framed by a black border), after its own systematic review indicated that such therapy was associated with an elevated risk of suicidal thinking, feeling and behaviour in young people.[1,2] In this issue of the International Journal of Epidemiology, Azevedo Da Silva and co-workers make a timely and important contribution to the evidence base for another controversial potential side effect: antidepressant medication might predispose individuals to type 2 diabetes.[3]
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