Abstract
Commentary: An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation
Highlights
Commentary: An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long
We have witnessed huge success of genome-wide association studies (GWASs) in identifying hundreds of susceptibility genetic variants associated with Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc), over 90% of which are located in noncoding regions
In our publication[4], we provided a mechanistic insight that a noncoding GWAS variant associated with both SLE and SSc acted as an allele-specific strong enhancer to directly regulate the distal gene IRF5 expression mediated by transcription factor EVI1 through the current robust strategies, including integrated multi-omics approaches and follow-up functional experiments
Summary
Commentary: An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-. *Correspondence: Dr Tie-Lin Yang, Ph.D., Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P.
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