Abstract
Commentary: Age-related neurodegenerative disease research needs aging models.
Highlights
In his recent article, Ian Johnson identifies a need for research into neurodegenerative diseases that makes use of animal models more closely resembling the complex, age-related reality of these diseases in people (Johnson, 2015)
Current animal models of neurodegenerative disease largely ignore the context in which many of these diseases arise; they are inextricably linked to aging
The accumulation of health deficits has been used to measure a person’s level of frailty, which can be conceptualized as a state of increased vulnerability to poor health outcomes that differs among people of the same chronological age (Mitnitski et al, 2001; Rockwood and Mitnitski, 2007; Clegg et al, 2013)
Summary
Ian Johnson identifies a need for research into neurodegenerative diseases that makes use of animal models more closely resembling the complex, age-related reality of these diseases in people (Johnson, 2015). Age-related neurodegenerative disease research needs aging models by Johnson, I. Commentary: Age-related neurodegenerative disease research needs aging models.
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