Abstract
Commentary: Adenosine A2A Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism.
Highlights
Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism
Despite some limitations regarding variability and reproducibility seen in the animal model of Parkinson’s disease (PD) induced by rotenone (Cannon et al, 2009), this model seems to replicate many hallmarks of illness including α-synuclein aggregation and Lewy body formation (Martinez and Greenamyre, 2012)
All subtypes of adenosine receptors have been found in the central nervous system
Summary
A commentary on Adenosine A2A Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism by Fathalla, A. Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism. A recently published paper by Fathalla et al (2016), demonstrated a rotenone induced possible protective effect of ZM241385 (a selective A2A receptor antagonist), but not of 8-cyclopentyl-1,3dipropylxanthine (a selective A1 receptor antagonist), in a rat model of Parkinson’s disease (PD).
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