Abstract
Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function
Highlights
NNOSμ expressed at the plasma membrane of skeletal muscle cells could act as a surrogate for nNOSα function
Key assumptions of this hypothesis include [1] the molecular similarity of the nNOSα and nNOSμ splice variants; [2] the mechanisms regulating nNOSα localization in neurons are similar to those regulating nNOSμ in skeletal muscle cells
While the study of isozyme-specific differences between nNOS splice variants is in its infancy, early studies suggest that μ insert inclusion reduces the speed of electron transfer from reductase to oxidase domains [3]
Summary
A hypothesis for examining skeletal muscle biopsy-derived sarcolemmal nNOSμ as surrogate for enteric nNOSα function by Chaudhury A. Dr Chaudhury puts forward an interesting hypothesis that reductions in sarcolemmal nNOSμ might parallel reductions in enteric neuron nNOSα expression, localization, and activity [1]. NNOSμ expressed at the plasma membrane (sarcolemma) of skeletal muscle cells could act as a surrogate for nNOSα function.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.