Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function

Justin M Percival

doi:10.3389/fmed.2015.00070

Abstract

Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function

Highlights

NNOSμ expressed at the plasma membrane of skeletal muscle cells could act as a surrogate for nNOSα function
Key assumptions of this hypothesis include [1] the molecular similarity of the nNOSα and nNOSμ splice variants; [2] the mechanisms regulating nNOSα localization in neurons are similar to those regulating nNOSμ in skeletal muscle cells
While the study of isozyme-specific differences between nNOS splice variants is in its infancy, early studies suggest that μ insert inclusion reduces the speed of electron transfer from reductase to oxidase domains [3]

Summary

Introduction

A hypothesis for examining skeletal muscle biopsy-derived sarcolemmal nNOSμ as surrogate for enteric nNOSα function by Chaudhury A. Dr Chaudhury puts forward an interesting hypothesis that reductions in sarcolemmal nNOSμ might parallel reductions in enteric neuron nNOSα expression, localization, and activity [1]. NNOSμ expressed at the plasma membrane (sarcolemma) of skeletal muscle cells could act as a surrogate for nNOSα function.

Objectives

Results

Conclusion