Abstract
Commentary: A Gene-Based Association Method for Mapping Traits Using Reference Transcriptome Data.
Highlights
U.S Department of Health and Human Services, Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA
Gene expression regulation mechanisms contribute to disease susceptibility, drug response, and the course of many substance-use disorders [1,2,3]
The investigators harnessed the power of large reference transcriptome data sets, such as the Genotype-Tissue Expression (GTEx) Project, the Genetic European Variation in Health and Disease (GEUVADIS), and Depression Genes and Networks (DGN), among others – in which both gene variation and gene expression levels have been measured – to estimate genetically regulated gene expression of single nucleotide polymorphism (SNP)
Summary
Gene expression regulation mechanisms contribute to disease susceptibility, drug response, and the course of many substance-use disorders [1,2,3]. Gamazon et al recently reported development of an innovative gene-based association method to further understanding of gene-expression regulation mechanisms mediating relationships between single nucleotide polymorphism (SNP) variations and phenotypic variability of complex traits [4].
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