Abstract
Commentary: A Cell Line for Detection of Botulinum Neurotoxin Type B.
Highlights
The quest for a viable, appropriate and validatable alternative assay to the mouse LD50 potency method is something that those working in the field of botulinum toxin (BoNT) have engaged with for decades
The mouse assay has been used as the long-standing gold standard for BoNT identification and serotype determination and for the routine assessment and quality release of BoNT commercial product batches used for clinical treatments worldwide
The work of Rust and colleagues, describing an alternative cell-based assay for serotype B BoNT, presents a sound, scientifically determined methodology that could be applied to the single commercial type B product available (Rust et al, 2017)
Summary
The quest for a viable, appropriate and validatable alternative assay to the mouse LD50 potency method is something that those working in the field of botulinum toxin (BoNT) have engaged with for decades. The work of Rust and colleagues, describing an alternative cell-based assay for serotype B BoNT, presents a sound, scientifically determined methodology that could be applied to the single commercial type B product available (Rust et al, 2017).
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