Comment on: Tikhonenko et al. (2010) Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated with a Decrease in Fatty Acid Elongases Elovl2 and Elovl4. Diabetes;59:219–227

Abstract

Tikhonenko et al. (1) recently reported that diabetes-induced changes in retinal fatty acid metabolism lead to a significant decrease in retinal n-3 polyunsaturated fatty acids (PUFAs), especially docos ahex aenoic acid (DHA). They proposed that these changes in fatty acid compositions may be related to the chronic inflammation that occurs in the diabetic retina. Even though they admitted it was possible that high levels of reactive oxygen species (ROS) cause the degradation of the highly oxidation-prone DHA molecule, Tikhonenko et …