Comment on: The Tube Versus Trabeculectomy IRIS® Registry Study: Cohort Selection and Follow-up and Comparisons to the Randomized Controlled Trial

Abstract

We read with interest the article by Vanner and colleagues entitled “The Tube Versus Trabeculectomy IRIS® Registry Study: Cohort Selection and Follow-up and Comparisons to the Randomized Controlled Trial.”1 The authors emulated the Tube Versus Trabeculectomy (TVT) randomized controlled trial (RCT) with electronic health record (EHR) data. They found that application of the TVT study criteria to the retrospective EHR cohort led to significant baseline differences between eyes having a glaucoma drainage device or trabeculectomy (trab), as opposed to the TVT RCT where the 2 groups were matched.