Abstract
In a recent article,1 Halle was critical of the use of the slowly relaxing local structure (SRLS) model2, 3 for the analysis of NMR spin relaxation in proteins.4, 5 Although he cited private communications with us, he did not discuss the contents of his article prior to its publication, nor were we aware of his intentions. We are in disagreement with a number of aspects of this article, but confine ourselves just to a brief rebuttal of his negative comments about SRLS and its use. We do, however, respect Halle’s efforts to provide a physical basis for the model-free (MF) approach.
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