Abstract
We thank Professors Blomstedt and Hariz for drawing our attention to the pioneering work of Brice and McLellan on tremor in multiple sclerosis [1]. These authors were the first to realise and demonstrate the potential of closed-loop control in Deep Brain Stimulation. Such control adjusts stimulation parameters in real-time based on continuous feedback input signals that reflect the patient's fluctuating clinical state, and has the potential to increase the therapeutic window available to patient and clinician.
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