Abstract
Tessari et al. (1) elegantly demonstrated—by a precursor-product stable isotope method—independent contributions of age, type 2 diabetes, and asymmetric dimethylarginine (ADMA) to impaired conversion of 15 N -labeled L-arginine into nitrite and nitrate (NOx), products of nitric oxide (NO) metabolism. Interestingly, the authors observed no associations of any parameter of NOx kinetics with insulin sensitivity by a hyperinsulinemic-euglycemic clamp technique (1). Our group was the first to report elevated plasma …
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