Comment on Prior et al. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes 2015;64:3386-3395.

Abstract

I read with great interest the recent article by Prior et al. (1), in which muscle biopsies and the hyperinsulinemic-euglycemic clamp were combined to interrogate the role of the exercise-induced increase in skeletal muscle capillarization on insulin sensitivity. Specifically, the effects of 6 months of endurance training and 2 weeks of detraining on intramuscular signaling, capillarization, and whole-body insulin sensitivity were determined in older sedentary individuals. This study represents a further step toward understanding …