Abstract
Comment on "microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes".
Highlights
I reconstructed 10,000 random microRNA data sets in which the “clusters” are formed by nonclustered microRNAs
Wang et al acknowledged that the methodology used was different
Wang et al (2016) wrote: “in the permutation analysis, we only randomly shuffled the locations of miRNAs.”
Summary
I reconstructed 10,000 random microRNA data sets in which the “clusters” are formed by nonclustered microRNAs. Wang et al acknowledged that the methodology used was different. Wang et al (2016) wrote: “in the permutation analysis, we only randomly shuffled the locations of miRNAs.” Wang et al (2018) reported instead that “[they] first shuffled the co-expressed seed: target pairing.” This point is critical as the reviewers of the original paper were unaware of the actual permutation method used, and this permutation method produces erroneously low Pvalues.
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