Abstract
Comment on "Impact of dose and sensitivity heterogeneity on TCP".
Highlights
In a reply to the comment [4], despite expressly treating “macroscopic intercell dose variations,” the authors refer to microdosimetrical energy deposition variations as motivating their assumption of large and statistically independent variations of absorbed dose over distances of a cell diameter; they write the following
One has to keep in mind that microdosimetrical measurements show large variations in specific energy for the same expectation/average value
It is impossible that “large variations in specific energy” could lead to large variations in the “expectation/average value” because the latter was supposed to be constant (“the same”)
Summary
In a reply to the comment [4], despite expressly treating “macroscopic intercell dose variations,” the authors refer to microdosimetrical energy deposition variations as motivating their assumption of large and statistically independent variations of absorbed dose over distances of a cell diameter; they write the following. There is no theoretical or experimental support for the occurrence of large and statistically independent variations of absorbed dose over distances of a cell diameter.
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