Abstract
We noted with interest the article (1) where evidence for hypoxia in white adipose tissue (WAT) of two mouse models of obesity was presented. This study indicated that the expression of some adipokine genes, including leptin and plasminogen activator inhibitor-1, are increased in WAT of obese animals, that adiponectin is decreased, and that the effects mirrored those in studies on mouse 3T3-L1 cells (1). These findings are consistent with …
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