Abstract
Acute promyelocytic leukemia (APL) is a unique and very deeply studied acute myeloid leukemia [...].
Highlights
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The typical molecular genetic feature of Acute promyelocytic leukemia (APL) is the rearrangement of RARA gene with PML and a few with other partner genes
There are still some rare cases lacking RARA fusion they share the same morphology and immunocytochemistry features with typical APL. The classification of such cases remains controversial. They are usually referred to as acute promyelocytic-like leukemias (APLL), and sometimes they were morphologically classified as M3 according to the FAB classification
Summary
Positive: CD13, CD33, CD117, CD56; negative: HLA-DR, CD34, CD38, CD15, CD14, CD7, CD2, CD3, CD4, CD8, CD19, CD20, CD10. ATRA+ATO, switched to IA, NR; HA, CR. Followed by 4 courses of HA and 1 course of EA as maintenance therapy [11]. Positive: MPO, CD13, CD33; partially positive: CD71, negative: CD14, CD19, CD34, CD38, CD64, CD117, CD11b, CD11c, HLA-DR
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