Abstract
I read with fascination the article by Ellervik et al. (1) demonstrating the increased risk of both type 1 and type 2 diabetes associated with elevated transferrin saturation levels. In accord with this, I previously reported significantly increased levels of total hemoglobin concentration in individuals with childhood-onset type 1 diabetes (2). Others have shown significantly higher androgen levels in both males and females with type 1 diabetes compared with nondiabetic controls (3). Androgens have a direct stimulatory effect on erythropoiesis. I agree with Ellervik et al. that very high iron concentrations may cause destruction of pancreatic β-cells in a nonautoimmune manner. However, I propose that other factors may …
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