Comment on “Do Neonatal Mouse Hearts Regenerate following Heart Apex Resection”?

Abstract

The recent article by Andersen et al. (2014) reports that following resection of the neonatal heart, “complete regeneration” does not occur, and contrasts these results with those of Porrello et al. (2011), who used a similar lesion model. The authors cite our work in support of the fact that complete regeneration does not occur within the neonatal mouse, as we reported that infarction of the neonatal mouse heart is accompanied by inflammatory repair, including CD45+ cell influx, fibrosis, and vascularization of the ablated region of the neonatal myocardium (Jesty et al., 2012).