Comment on: Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

Siamak Sabour

doi:10.1186/s13000-020-01055-2

Abstract

Comment on: Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

Highlights

While the article offers insight into the decision that MiR-186-5p is a possible diagnostic biomarker for patients with asymptomatic carotid artery stenosis (CAS) and predicts the incidence of future cerebral ischemic events (CIEs), its conclusion is restricted in three ways
Correspondence: s.sabour@sbmu.ac.ir 1Department of Clinical Epidemiology, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IR, Iran 2Safety Promotions and Injury Prevention Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, IR, Iran knowledge is the information required to address the issue, “What is the possibility of the presence or absence of a particular disease given these test results? “ (Research for diagnostic accuracy)
I should mention that as high miR-186-5p level and high degree of carotid stenosis were independent factors for the occurrence of CIEs, one might consider the specificity of these two factors be combined

Summary

Introduction

I read the article by Lv et al published in Diagn Pathol 2020. They aimed to investigate the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosis (CAS), and its predictive value for future cerebral ischemic events (CIEs) [1]. While the article offers insight into the decision that MiR-186-5p is a possible diagnostic biomarker for patients with asymptomatic CAS and predicts the incidence of future CIEs, its conclusion is restricted in three ways. First,knowledge of the reported estimates does not provide overall information on the diagnostic and prognostic value of MiR-186-5p in clinical practice. Diagnostic added value is much more important for clinical purposes than the estimates stated [2–5].

Results

Conclusion