Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-Aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro

Abstract

We are writing to express our merit-based concerns about the study “Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro” by Valente et al. recently published in ACS Nano 2020, 14, 6866–6877. There are numerous reasons for which to believe that this study on conopeptide-functionalized gold nanoparticles is fundamentally flawed, contains incorrect or misleading statements, and its title and conclusions are not supported by the data presented.