Comment on Clinical Trial NCT00950001 and NCCTG/N107C/CEC.3: Are We Treating Cancer or Water?

Junfang Gao

doi:10.4236/ijmpcero.2021.101002

Abstract

During the implementation of clinical trials NCT00950001 and NCCTG/N107C/CEC.3 on post-operative stereotactic radiosurgery into clinic, it brought us some thinking of fundamental concept in science that the local control rate and survival rate rely on the treatment of marginal region more than resection cavity. Marginal region might still contain residual cancer cell while the resection cavity contains only water fluid most time. Radiation treatment should focus more on the margin rather than the cavity, thus treating cancer rather than water.

Highlights

During the implementation of clinical trials NCT00950001 and NCCTG/ N107C/CEC.3 on post-operative stereotactic radiosurgery into clinic, it brought us some thinking of fundamental concept in science that the local control rate and survival rate rely on the treatment of marginal region more than resection cavity
In the NCCTG/N107C/CEC.3 trial, Dr Brown and colleagues compared the medical outcome between SRS and WBRT among brain metastasis resection patients within 48 institutes
Even though some comments and criticisms have been addressed by other doctors [3] [4], these two informative clinical trials will potentially establish a standard guideline for clinicians in the treatment of post-operative brain metastasis patients

Summary

Introduction

During the implementation of clinical trials NCT00950001 and NCCTG/ N107C/CEC.3 on post-operative stereotactic radiosurgery into clinic, it brought us some thinking of fundamental concept in science that the local control rate and survival rate rely on the treatment of marginal region more than resection cavity. Marginal region might still contain residual cancer cell while the resection cavity contains only water fluid most time. Radiation treatment should focus more on the margin rather than the cavity, treating cancer rather than water.

Results

Conclusion