Abstract
Comment on "Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera".
Highlights
In the article by Omabe et al, type 2 diabetes has been induced by a single intraperitoneal injection of alloxan, which is not correct due to its mechanism of action
Alloxan acts in two ways: it selectively inhibits glucose-induced insulin secretion through speci c inhibition of glucokinase, the glucose sensor of the beta cell, and it causes a state of insulin-dependent diabetes through its ability to induce reactive oxygen species (ROS) formation, resulting in the selective necrosis of pancreatic beta cells [2, 3]. erefore, alloxan cannot induce type 2 diabetes
Summary
In the article by Omabe et al, type 2 diabetes has been induced by a single intraperitoneal injection of alloxan, which is not correct due to its mechanism of action.
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