Abstract
AbstractHydration of the double bond of some stilbene congeners of Picea abies bark by TiCl4·NaBH4 reagent is described. Five racemic 1,2‐diphenylethanol derivatives (9–13), structurally related to (R)‐(·)‐combretastatin [(R)‐1], have been obtained and characterized mainly by 13C‐ and 1H‐NMR as well as mass spectrometry. The antileukemic activity of each compound has preliminarily been tested by the mouse leukemia L1210 system. Compound 10 has been synthesized by Friedel‐Crafts acylation.
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