Abstract
Abstract Functional magnetic resonance imaging (fMRI) complements non-invasive transcranial brain stimulation (NTBS) in multiple ways. Task or resting-state data acquired before NTBS can be used to identify or individualize stimulation targets. Individual network connectivity patterns have already been associated with differences in the treatment response to transcranial magnetic stimulation (TMS) and might be useful biomarkers for future personalized NTBS treatments. FMRI has also been used to characterize the aftereffects of stimulation on brain activity. This approach revealed effects in remote brain regions that are not directly targeted by NTMS. These remote network effects show a complex dependency on stimulation parameters and brain state. Finally, applying NTBS online during fMRI allows for the direct assessment of immediate stimulation effects, but online fMRI is technically more challenging. Online combinations of NTBS with fMRI have confirmed that NTBS induces changes in brain activity at the network level and might be useful to reveal the individual dependency of the induced activity changes on the NTBS stimulation dose. This may be particularly relevant for NTBS targeting nonmotor brain areas.
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