Abstract
Acoustic Force Spectroscopy (AFS) is a single-molecule force spectroscopy technique that uses standing ultrasound waves generated by a piezo element to apply forces to DNA, proteins and cells in a well-controlled and multiplexed way. Here, we integrate AFS with fluorescence microscopy to allow correlations between force and fluorescence signatures. This is particularly useful to define the number of (fluorescently labelled) ligands bound to a DNA or protein molecule, allowing us to extract multiple populations from the same measurement.
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