Abstract
This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C-H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very exciting research line. In particular, the development of proteins with the ability to perform C-H functionalization presents a significant challenge. Here we discuss the development of these processes on natural metalloenzymes by using directed evolution, biotin-(strept)avidin technologies, photocatalytic hybrids or reconstitution of heme-protein technology.
Highlights
In the last few years, the creation of new artificial metalloenzymes by the combination of metal or complex organometallic systems and enzymes has represented a very exciting line of research
Alba Rodríguez Otero was born in Madrid, Spain (1996). She is currently finishing her degree in Chemical Engineering from Universidad Autónoma de Madrid (UAM)
A second approach to produce artificial metalloenzymes is based on anchoring a metal cofactor within a protein, combining characteristics that typically are from homogeneous catalysts with those from enzymes (II, Fig. 2).[14,17]
Summary
In the last few years, the creation of new artificial metalloenzymes by the combination of metal or complex organometallic systems and enzymes has represented a very exciting line of research. Alba Rodríguez Otero was born in Madrid, Spain (1996) She is currently finishing her degree in Chemical Engineering from Universidad Autónoma de Madrid (UAM). The third strategy consists of the replacement of the existing metal ion or organometallic complex inside the natural metalloenzyme with an alternative one (III, Fig. 2), mainly using engineered heme-containing proteins.[16,17] The application of these biocatalysts in organic chemistry has been a major challenge in the last few years. Jose has published more than 140 articles in high-impact journals, with more than 7000 citations (H-index of 42) His current research interests are in protein chemistry, nanocatalysis, nanobiotechnology, glycochemistry, chemical biology and biocatalysis. This mini-review focuses on describing the few examples that up to now exist in the literature about the creation of artificial metalloenzymes with C–H activation activity
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