Abstract

A study was conducted on the influence of single and combined carriers on the dissolution rate of tolbutamide from its coprecipitates. All of the water-soluble carriers investigated enhanced the dissolution rate of tolbutamide, but the combination of 40% polyethylene glycol 6000-60% dextrose as the carrier for a 1:1 coprecipitate yielded the most rapid dissolution of tolbutamide. Other carriers used were polyethylene glycol 6000, polyethylene glycol 4000, dextrose, and mannitol, alone or combined in various proportions.

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