Combined use of recombinant interlekin-2 and anthelmintic drugs for the treatment of helminthiasis of animals

Abstract

Relevance. The widespread occurrence of helminthiasis leads to significant economic damage: loss of production, decreased fertility, significant costs for therapeutic and preventive measures, culling and mass death of domestic animals (especially young animals). Parasitization of helminths observed in farm animals is associated with the development of immunodeficiency. Deworming, as a rule, also leads to certain negative changes in the immune system.Methods. The use of combination therapy, including the use of anthelmintic drugs in combination with recombinant interleukin-2 (Roncoleukin®) for the treatment of helminthiasis of animals of various etiologies.Results. The use of anthelmintics in combination with pathogenetic therapy with recombinant interleukin-2 promotes the restoration of immunoreactivity of animals, reduces the likelihood of adverse reactions and improves the results of deworming. The use of combination therapy in cattle, horses and pigs increases the effectiveness of the treatment of helminthiasis: there is a significant decrease in the intensity of invasion by 2, 8, 19 times and the extent of invasion by 7, 13, 21%, an increase in the values of intensity effectiveness by 8, 13, 25% and extensivity by 7, 16, 21%. The use of the combined deworming method contributes to a significant increase in the average daily weight gain of animals in comparison with monotherapy with anthelmintic drugs.