Abstract
Objective: It was found that GnRH has receptors in the whole male and female reproductive tract: testis, cumulus complex, oocytes, fallopian tubes, endometrium, etc. The GnRH Analogue (GnRHA) has a beneficial effect at all levels while the GnRH Antagonist opposes it with an apparent trend toward lower pregnancy rates. However, the GnRH Antagonist is becoming more accepted because of a lesser incidence of O.H.S.S. and less cycle cancellations especially, in the challenging P.C.O.S. cases (multiple smaller than 12mm follicles with high Estradiol (E2)). Our pilot study attempts to determine if the beneficial effects of the GnRHA can be maintained and further enhanced by the timely addition of the GnRH Antagonist.
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