Abstract
Background Currently, the most effective method to combat the COVID-19 pandemic is vaccination. This study investigated whether the combined use of vaccines obtained by different methods affected the side-effect profile.
 Methods This cross-sectional study evaluated 437 people (265 females, 172 males; mean age, 42.04±14.49 years) who applied to the emergency department due to side effects among 26,974 vaccinated people (13,460 females, 13,514 males). The complaints and outcomes of the patients who applied to the emergency department were recorded.
 Results While the rate of admission to the emergency department due to post-vaccination side effects was 1.6% among all vaccinated participants, this rate was 3% in the mixed vaccination group. It was observed that hospitalization was required in only two patients due to side effects. When vaccination methods were compared, the frequency of admission to the emergency department due to side effects was higher in the patients in the group in which the mRNA vaccine was mixed with the booster shot. However, it was not statistically significant (p=0.113).
 Conclusion Different vaccine methods did not change the side effect profile, so different vaccine combinations could be used together if necessary.
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