Abstract
AIM:To investigate the efficacy of combined use of different blood purification methods in the treatment of severe acute pancreatitis(SAP)and explore the therapeutic mechanisms involved. METHODS:Sixty-one SAP patients were randomly divided into control group(n=29)and treatment group(n=32).Patients in the control group underwent conventional therapy,while those in the treatment group underwent conventional therapy and blood purification[including continuous high-volume hemofiltration(CHVHF),hemoperfusion(HP),and peritoneal dialysis(PD)].The efficacy was compared between the two groups. RESULTS:Compared with the control group, the duration of abdominal pain relief was sig-nificantly shortened,ascitic amylase level was significantly reduced,and APACHE II score and CT severity index(CTSI)were significantly improved in the treatment group.The response rate achieved in the control group was significant lower than that in the treatment group (72.41%vs 90.63%,P0.05),while the mortality rate in the control group was significant higher than that in the treatment group(27.59%vs 9.38%,P0.01). CONCLUSION:Blood purification can rapidly improve clinical symptoms and reduce mortality rate in SAP patients,and is therefore effective for treatment of SAP.Combined use of CHVHF, HP and PD has better efficacy in the treatment of extremely severe cases of SAP than either method alone.
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