Year-end Sale % OFF 
Abstract
The literature review is devoted to the analysis of the main methods of treatment of patients with colorectal cancer liver metastases. The analysis of the clinical trials results over the past 10 years has been carried out. Colorectal cancer is the common malignant neoplasm. About 20% of patients have distant metastases in the diagnosing. Liver is the most frequent targeted organ, liver metastases are detected in 14,5% of patients with colorectal cancer. Despite the encouraging results of treatment of certain groups of patients with metastatic colorectal cancer, the treatment tactics for most patients is limited to palliative chemotherapy. In recent years, the survival of patients with metastatic colorectal cancer has significantly improved due to the success of systemic therapy. The median overall survival has reached for 2 years due to combination chemotherapy based on fluoropyrimidines, oxaliplatin, irinotecan in combination with monoclonal antibodies (bevacizumab, cetuximab and panitumumab). The optimal combination and sequence of using these anticancer agents in the treatment of metastatic colorectal cancer has not yet been determined. Surgery is the standard of care for this category of patients. At the same time, until nowdays there are no clear and generally accepted criteria for choosing the optimal volume of surgical intervention, prescribing first-line chemotherapy and using other methods of antitumor treatment.
Highlights
Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г
The literature review is devoted to the analysis of the main methods of treatment of patients with colorectal cancer liver metastases
Liver is the most frequent targeted organ, liver metastases are detected in 14,5% of patients with colorectal cancer
Summary
Kostromitsky D.N.*, Dobrodeev A.Y., Afanasyev S.G., Tarasova A.S. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia; 5, Kooperativny lane, Tomsk, 634009, Russian Federation. The literature review is devoted to the analysis of the main methods of treatment of patients with colorectal cancer liver metastases. The survival of patients with metastatic colorectal cancer has significantly improved due to the success of systemic therapy. Был сделан вывод о том, что у больных с МКРР в печени ПСР безопаснее и эффективнее по сравнению с ОРП, поскольку при сопоставимых отдаленных результатах приводят к уменьшению числа интра- и послеоперационных осложнений. При этом медиана общей выживаемости после резекции печени в группе с PVE составила 38,9 мес по сравнению с 45,6 мес в группе без PVE, а время до прогрессирования – 15,2 и 21,7 мес (p < 0,005). Медиана наблюдения в обеих группах составила 35,9 мес, при этом медиана времени до прогрессирования в группе FOLFOXIRI и бевацизумаба была достоверно больше – 19,2 мес, чем в группе FOLFIRI и бевацизумаба – 16,4 мес (p = 0,0005). Благодаря внедрению в повседневную практику агрессивных методов хирургических вмешательств, большого числа современных химиопрепаратов и биологических противоопухолевых агентов появляется возможность радикального излечения больных этой категории с общей и безрецидивной выживаемостью, не уступающей выживаемости при III стадии КРР
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
