Abstract
How to eradicate methicillin-resistant Staphylococcus aureus (MRSA) colonization in hospitalized patients is uncertain. We reviewed our experience with MRSA decolonization therapy in hospitalized patients. An 1100-bed, university-affiliated tertiary care teaching hospital in Toronto, Ontario. Retrospective chart review of 207 adult inpatients with MRSA colonization hospitalized between February 1996 and March 1999. All patients with MRSA colonization were assessed for possible decolonization therapy with a combination of 4% chlorhexidine soap for bathing and washing, 2% mupirocin ointment applied to the anterior nares three times/day, rifampin (300 mg twice daily) and either trimethoprim/sulfamethoxazole (160 mg/800 mg twice daily) or doxycycline (100 mg twice daily). This treatment was given for seven days. A total of 207 hospitalized patients with MRSA colonization were identified and 103 (50%) received decolonization therapy. Patients who received decolonization therapy were less likely than untreated patients to have intravenous (P=0.004) or urinary catheters (P<0.001), or extranasal sites of colonization (P=0.001). Successful decolonization was achieved in 90% of the 43 patients who were available for at least three months of follow-up. Combined topical and oral antimicrobial therapy was found to be effective in eradicating MRSA colonization in selected hospitalized patients, especially those without indwelling medical devices or extranasal sites of colonization.
Highlights
When methicillinresistant Staphylococcus aureus (MRSA) was recovered again after decolonization therapy, the pre- and post-treatment isolates were typed by pulsed-field gel electrophoresis (PFGE) following DNA extraction and digestion with SmaI [15]
Potential indications for attempting to eradicate MRSA colonization in hospitalized patients include the prevention of serious infections in an individual, and the interruption of transmission within a health care facility
There are concerns regarding the effectiveness of the strategy and the emergence of antimicrobial resistance to the agents used [4,24,25,26,27]
Summary
Combined topical and oral antimicrobial therapy for the eradication of methicillin-resistant. Combined topical and oral antimicrobial therapy for the eradication of methicillinresistant Staphylococcus aureus (MRSA) colonization in hospitalized patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Similar Papers
More From: Canadian Journal of Infectious Diseases and Medical Microbiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.