Abstract
Combined Therapy Effect of D-002 and Omeprazole on Chronic Esophagitis Induced by Duodenal Reflux in Rats
Highlights
IntroductionGastroesophageal reflux disease (GERD) occurs when the stomach and duodenum content are regurgitated into esophagus, causing mucosal lesions and esophageal tissue changes [1]
Gastroesophageal reflux disease (GERD) occurs when the stomach and duodenum content are regurgitated into esophagus, causing mucosal lesions and esophageal tissue changes [1].Gastroesophageal reflux leads to the adenocarcinoma (ADC) development that is one of its complications
The positive control group animals showed a significant increase of the ILE and the histological score with respect to negative control group, not subjected to duodenum-esophageal reflux (DER)
Summary
Gastroesophageal reflux disease (GERD) occurs when the stomach and duodenum content are regurgitated into esophagus, causing mucosal lesions and esophageal tissue changes [1]. Gastroesophageal reflux leads to the adenocarcinoma (ADC) development that is one of its complications. In recent years the ADC incidence has increased faster than other tumors [2]. Numerous studies investigate the ADC formation mechanism from GER that include both gastric and duodenal juices refluxed [3,4]. Differences between gastric and duodenal juice-induced damage was established, and non-acid (duodenal) reflux showed to be important in the progression from Barrett’s esophagus (BE) to ADC, confirming that duodenal juice may induce EB and ADC in rats [5,6]. The increase of ADC incidence is related to the acid suppression [7,8]
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