Abstract
Background: In this paper, we aim to explore clinical value of skeletal muscle index (SMI) and prognostic nutrition index (PNI) on resected colorectal cancer liver metastasis (CRLM).Results: Among the 539 patients, 355 were males. Baseline lower SMI was associated with smaller BMI, smaller PNI, smaller pre-albumin and longer hospitalization days (P<0.05). Patients with lower SMI and PNI had significantly shorter duration of PFS and OS (P<0.05). SMI can reflect the postoperative treatment response. Postoperative 6-month’s and 12-month’s SMI and PNI can indicate overall prognosis. When combined SMI and PNI, prognostic AUC of ROC curves improved significantly.Conclusion: Combined monitor of SMI and PNI can improve the power at predicting prognosis. Postoperative 6-month’s record of SMI and PNI was more accurate and predictive for CRLM prognosis.Method: A total of 539 resected CRLM patients between January 2013 to December 2016 with complete clinical data were included. Computed tomography image was collected from each patient. Receiver-operating characteristic (ROC) curves were constructed; area under curves (AUC) were also determined. All clinical variables were analyzed in proper way.
Highlights
Colorectal cancer (CRC) is one of the most common malignancies of digestive gastrointestinal tract [1, 2]
We found that T stage (P-value=0.02), tumor differentiation (P-value=0.01), Baseline skeletal muscle index (SMI) level (P-value
Surgery remains the cornerstone in the multimodal treatment of cancer liver metastasis (CRLM) [4, 11, 28]
Summary
Colorectal cancer (CRC) is one of the most common malignancies of digestive gastrointestinal tract [1, 2]. Many bodycomposition markers, such as skeletal muscle index (SMI) and prognostic nutrition index (PNI) have been reported to be associated with survival, complication and hospitalization in patients [5,6,7,8]. With regard to these factors, loss of SMI has been proven to be significantly present in cancer patients with distant metastasis [9]. We aim to explore clinical value of skeletal muscle index (SMI) and prognostic nutrition index (PNI) on resected colorectal cancer liver metastasis (CRLM).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have