Combined radiotherapy-chemotherapy of lewis lung carcinoma

Abstract

Intramuscular implants of Lewis lung tumor have been treated with combinations of cyclophosphamide and local irradiation. The results were assessed in terms of long-term tumor control and early skin damage. The cyclophosphamide treatment reduced the radiation dose required for cure from about 4200 to 1200 rad, and it was best to give the two treatments within a day of one another. Radiation-induced skin damage was not increased by cyclophosphamide treatment, and these results therefore indicate that the combination has a useful therapeutic advantage.