Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler

Audrey K Ellerbee Bowden,Caroline Boudoux,Kristen L Lurie,Lucas Mageau,Mathias Strupler,Nicolas Godbout,Robin Guay-Lord,Xavier Attendu

doi:10.1117/12.2211758

Audrey K Ellerbee Bowden, Caroline Boudoux + Show 6 more

Open Access

https://doi.org/10.1117/12.2211758

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Publication Date: Mar 10, 2016
Citations: 1	License type: cc-by

Affiliation: Polytechnique Montréal, Stanford University

Abstract

This proceedings shows the combination of Optical Coherence Tomography (OCT) and Hyper-Spectral Imaging (HSI) using a double-clad optical fiber. The single mode core of the fiber is used to transmit OCT signals, while the cladding, with its large collection area, provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of sample morphology with OCT, enhanced by the molecular information contained in its hyper-spectral image. We believe that the combination of these techniques could result in endoscopes with enhanced tissue identification capability.

Highlights

Over the last decade, optical coherence tomography (OCT) has developed into a significant clinical imaging modality
While other groups have reported combining OCT and hyperspectral imaging (HSI) in free-space systems,[26,27] we present an allfiber implementation based on a double-clad fiber (DCF)
The slight loss in axial resolution could be explained by a small dispersion mismatch between the sample and reference arm induced by the addition of the double-clad fiber coupler (DCFC)

Summary

Introduction

Optical coherence tomography (OCT) has developed into a significant clinical imaging modality. It has become a primary technique to investigate the eye[1] and blood vessels,2and many applications are emerging in laryngology,[3] gastroenterology,[4,5] dentistry,[6] and many other fields of medicine. OCT has the ability to image organs in threedimensions (3-D), with a resolution of a few micrometers, and a penetration depth of several millimeters at video rate acquisition speeds.[7] while OCT is a very powerful technique to assess sample morphology, it gives access to little molecular information. Hyperspectral imaging (HSI) is an imaging method that provides two-dimensional images of a sample in multiple wavelength bands.[8] A reflectance (or fluorescence) spectrum is associated with each pixel and conveys information on molecules present locally, but without depth discrimination. The technique has been successfully applied in cancer detection,[9,10,11] diagnosis of circulatory and[12,13,14] retinal15–17diseases, and surgical guidance.[18,19,20]

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