Combined nefopam-fentanyl use in PCA for postoperative analgesia in spinal surgery patients: a randomized, controlled, single-blind trial

Abstract

Background & objective: The use of fentanyl to manage postoperative pain in spinal surgery patients is common, although there have been concerns about potential of drug abuse and dependence. We investigated the effects of the combined administration of nefopam and fentanyl through intravenous (IV) patient-controlled analgesia (PCA) on early postoperative pain and possible side effects in patients undergoing spinal surgeries. Methodology: In this randomized, controlled study, 70 patients were allocated to receive either fentanyl 10 µg/mL (Group F) or fentanyl 10 µg/mL with nefopam 1.2 mg/mL (Group FN), with a total PCA volume of 100 mL per infusion bag. Patients received a background dose of 0.25 µg/kg/h and bolus dose of 0.5 mL SOS (fentanyl 5 µg). The lockout interval was set at 10 min and upper limit was set at 15 mL/4 h. The PCA parameters were set according to the body weight of each patient. Results: The cumulative postoperative fentanyl consumptions after 48 h for Group F and Group NF were reported as 744.6 ± 94.2 µg and 631 ± 62.5 µg (P < 0.05) respectively. The average number of bolus doses requested by the patients in Group F and FN were 20.8 ± 11.0, and NF 11.4± 7.6). The A/D ratio of both groups for the bolus doses were 70%. Group NF consistently scored a lower VAS and VAS-D score during the 48-hour postoperative period. However, the VAS scores significantly differ statistically between groups at 1, 6, 9, and 12 hours. Within group differences, the VAS score differed significantly statistically during the 0-1, 1-2, and 2-3 hours for Group F, while 24-36 hours for Group NF. Conclusion: The inclusion of nefopam in patient-controlled analgesia for spine surgery patients significantly reduced total use of fentanyl within the 48 hours postoperatively after the surgery. Patients receiving fentanyl with nefopam consistently had lower VAS scores at different time points. Abbreviations: PCA - patient-controlled analgesia; VAS - Visual Analogue Scale Keywords: postoperative pain, fentanyl, nefopam, patient-controlled analgesia Citation: Le XD, Nguyen ML, Nguyen DT, Do TH, Nguyen HG. Combined nefopam-fentanyl use in PCA for postoperative analgesia in spinal surgery patients: a randomized, controlled, single-blind trial. Anaesth. pain intensive care 2024;28(4):687−691; DOI: 10.35975/apic.v28i4.2370 Received: January 06, 2024; Reviewed: April 14, 2024; Accepted: April 14, 2024