Abstract
BackgroundNon-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocyanin (CPC) from Spirulina platensis on gastric ulcer in rats.MethodsMale Sprague–Dawley rats were divided into five groups: normal, aspirin (700 mg/kg bw), LBP (aspirin + 100 mg/kg bw/d LBP), CPC (aspirin + 50 mg/kg bw/d CPC), and MIX (aspirin + 50 mg/kg bw/d LBP + 25 mg/kg bw/d CPC) groups. Gastric ulcer was developed by daily oral feeding of aspirin for 8 weeks. Treatments were given orally a week before ulcer induction for 9 weeks.ResultsThe MIX group elevated gastric cyclooxygenase-1, prostaglandin E2, and total nitrite and nitrate levels by 139%, 86%, and 66%, respectively, compared with the aspirin group (p < 0.05). Moreover, the MIX group reduced lipid peroxides malondialdehyde levels by 78% (p < 0.05). The treatment of LBP and/or CPC increased gastric Bifidobacterium relative abundance by 2.5–4.0 times compared with the aspirin group (p < 0.05).ConclusionsWe conclude that combined LBP and CPC enhance gastroprotective factors, inhibit lipid peroxidation, and increase gastric Bifidobacterium relative abundance. Combined LBP and CPC have protective potential against gastric ulcer caused by aspirin in rats.
Highlights
Peptic ulcer is a common disease of the digestive system [1]
Combined Lycium barbarum polysaccharides (LBP) and C-phycocya‐ nin (CPC) have protective potential against gastric ulcer caused by aspirin in rats
The aim of this study was to investigate whether Lycium barbarum polysaccharides and/or C-phycocyanin could have healing potential on gastric ulcer caused by aspirin in rats
Summary
Peptic ulcer is a common disease of the digestive system [1]. Peptic ulcer is characterized by the erosion of mucosa, submucosa, and muscular layers on the lower esophagus, stomach, or duodenum [1]. The gastroprotective factors include antioxidants, bicarbonate, mucin, nitric oxide (NO), and prostaglandins (PGs) in the gastric mucosa. The damaging factors include oxidative stress, gastric acid, Helicobacter pylori, and non-steroidal antiinflammatory drugs (NSAIDs). Low-dose (75–325 mg/d) aspirin was used for the protection and therapy of cardiovascular disease. Chronic use of low-dose aspirin was associated with increased ulcer complications [7]. Aspirin could decrease gastric total nitrite and nitrate (NOx) which can act as a protective factor to stimulate gastric blood flow and mucin secretion [9, 10]. Aspirin increased oxidative stress by reducing gastric superoxide dismutase activity [11]. Non-steroidal anti-inflammatory drugs such as aspirin are used for the treatment of cardiovascular disease. Chronic use of low-dose aspirin is associated with the occurrence of gastric ulcer. The aim of this study was to investigate the healing potential of Lycium barbarum polysaccharides (LBP) from Chinese Goji berry and C-phycocya‐ nin (CPC) from Spirulina platensis on gastric ulcer in rats
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