Combined intensive chemoradiotherapy for organ preservation in patients with resectable and non-resectable oesophageal cancer

Abstract

From January 1990 to April 1993, 60 oesophageal cancer patients were enrolled in a protocol of non-surgical treatment that consisted of induction chemotherapy followed by concurrent chemoradiotherapy. Induction chemotherapy consisted of cisplatin 40mg/m 2 intravenous bolus days 1, 2, 14, 15; 24 h continous infusion of 5-fluorouracil (5-FU) 1000 mg/m 2 days 1 and 14; leucovorin 20 mg/m 2 days 1 and 14 given before and with 5-FU; bleomycin 30 UI days 1 and 14; mitomycin C 10 mg/m 2 day 14. Concurrent chemoradiotherapy consisted of 60 Gy (6 weeks) from day 21 and cisplatin 70 mg/m 2 days 28, 42 and 56; leucovorin 20 mg/m 2 followed by 5-FU 425 mg/m 2 days 28, 35, 42, 49 and 56. Complete response occurred in 44 of 55 evaluable patients (80%). The median survival is 32 months; the actuarial survival at 40 months is 35% (CI 18–53). These results appear improved over those reported with surgery or radiation alone, and suggest that organ preservation as a secondary treatment goal should be vigorously investigated.