Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction, tissue hypoxia and resistance to radiation therapy. Connective tissue growth factor (CTGF) plays a key role in development of fibrosis and tumor progression, therefore, representing an attractive therapeutic target for the treatment of PDAC. Particle therapy with carbon ions is less dependent on oxygen enhancement ratio (OER) and has produced encouraging phase 1/2 clinical data in PDAC. We aimed to investigate the effect of combined CTGF-inhibition and photon vs carbon radiation therapy.
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More From: International Journal of Radiation Oncology*Biology*Physics
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