Abstract
Combined heart-kidney transplantation may be performed in carefully selected patients with end-stage heart disease and renal failure. There are two types of combined transplantation of heart and kidney: 1) simultaneous heart-kidney transplantation (SHKT) from the same donor; 2) staged transplantation of heart and kidneys from two genetically different donors. The ISHLT registry in 2014 reported an increase in the number of SHKT over the years: from 22 in 1994 to 97 in 2012. World experience demonstrated excellent results of SHKT. Recipients of SHKT had superior survival, lower rates of acute cardiac and renal rejection compared to heart recipients. This article discusses the indications for simultaneous or staged heart-kidney transplantation in patients with dialysis-independent or dialysis-dependent renal failure, results and posttransplant survival of SHKT recipients. The author describes his own experience of 2 staged combined heart-kidney transplantations.
Highlights
Combined heart-kidney transplantation may be performed in carefully selected patients with end-stage heart disease and renal failure
Recipients of SHKT had superior survival, lower rates of acute cardiac and renal rejection compared to heart recipients
This article discusses the indications for simultaneous or staged heart-kidney transplantation in patients with dialysis-independent or dialysis-dependent renal failure, results and posttransplant survival of SHKT recipients. The author describes his own experience of 2 staged combined heart-kidney transplantations
Summary
Трансплантацию сердца–почки от одного и того же донора, а также последовательные (staged) трансплантации сердца и почки от двух генетически различных доноров [1]. Первый опыт комбинированной трансплантации сердца и почки (КТСП) принадлежит D.A. Cooley и соавт. M.R. Vossler et al (2002) утверждают, что предтрансплантационный уровень креатинина более 1,6 мг/дл следует рассматривать в качестве предиктора развития ХПН после ТС и показанием к трансплантации и сердца, и почки [10].
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