Abstract
The aim of the present study was to identify ovine genomic regions and candidate genes impacting on milk traits i.e. milk yield, fat content, protein content and lactose content in the Frizarta dairy sheep. A total number of 481 ewes genotyped with the OvineSNP50 BeadChip were used. Haplotype regression analysis along with multi-locus mixed model analysis was employed to detect genomic markers associated with the traits. A total number of 9 single nucleotide polymorphisms were found to be associated with the traits under study. Four out of the 9 significant markers resided in genomic areas previously associated with milk traits according to the SheepQTLdb (http://www.animalgenome.org/cgi-bin/QTLdb/OA/search). A total number of 29 positional candidate genes located within a maximum distance of 250 kb upstream and downstream of 5 significant markers were identified. Gene prioritization analysis of the positional candidate genes based on the guilt-by-association principle suggested eleven genes i.e. ITGB4, H3F3B, ACOX1, WBP2, HTR1A, GPC5, GALR2, UNC13D, PRPSAP1, SRP68 and CDK3 as the most plausible functional candidate genes for milk traits in the Frizarta dairy sheep.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
