Abstract
The study was conducted to investigate the safety of combined extracts of Bryophyllum pinnatum (family: Crassulaceae) and Aloe barbadensis (family: Xanthorrhoeaceae) in rats. Forty rats were randomly selected and divided into four groups. Rats in groups I were administered with placebo as the control animals, while rats in groups II, III and IV were administered with aqueous extracts at 25mg/ml, 50mg/ml and 100mg/ml respectively for 28 days. Five milliliter (5ml) of blood was collected from either the ocular vein or aorta of each animal for evaluation of baseline and post – treatment values of AST, ALP, ALT, BUN, Total protein, and Creatinine, WBC, RBC, Platelet, MCV, MCH and MCHC. Data were expressed as Mean±Standard Error of Mean and analyzed using oneway ANOVA. Difference of means was considered statistically significant at P 0.05). Rats in groups II, III and IV exhibited significant increase in values of WBC, RBC, Platelet, MCV and MCH (P 0.05). Administration of the combined extracts may be tolerated at ≤25mg/kg bodyweight, if prolonged administration is avoided.
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