Abstract

Gold nanoparticle–piroxicam anion conjugates (Au NP–Pir) were synthesized in a green method using laser ablation of a gold foil in an aqueous solution of anionic piroxicam (NaPir). The produced Au NP–Pir conjugates were characterized by different spectroscopic techniques and transmission electron microscopy. The fluorescence and absorption spectra of Au NP–Pir colloidal solution were recorded at different concentrations of the Au NPs to investigate the effect of conjugation on the spectral properties of both the free Pir anion and Au NPs. Comparing the FT-IR spectrum of the colloidal solution of Au NP–Pir with that of the solution of the free Pir anion indicates that this anion binds to the surface of Au NPs through its different binding sites, viz., the pyridyl nitrogen atom, the SO2 group, and the amide oxygen atom. To support the experimental observations, theoretical calculations were also performed to evaluate the interaction of different binding sites of Pir with one Au atom and the effect of this i...

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